Methotrexate, alcohol, and liver damage.
نویسندگان
چکیده
منابع مشابه
Alcohol and liver damage
Chronic heavy drinking can cause the liver to become fatty. Fat deposits in the liver block the liver cells from their blood supply, depriving them of oxygen and other nutrients, eventually killing them. As the name implies, the liver performs so many vital functions that we cannot live without it. The liver filters all of the blood in our bodies, breaking down and eliminating toxins, convertin...
متن کاملAlcohol and liver damage.
The association of aicohol with cirrhosis was recognised by~vfatthew Ba-ilhe4& 1793 and later by Addison. In Western countries the incidence of cirrhosis canbe directly related to the quantity of aicohol consumed. In France, between—1941 and 1947, rationing of wine from five to one litre per week led to an 80% reduction in mortaiity from cirrhosis (1). Cirrhosis is on the increase. In the U.S.A...
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Objective(s): In this study, we evaluated the therapeutic effects of casticin and myricetin on liver damage induced by methotrexate in rats.Materials and Methods: Thirty-six male rats were used for the study and divided into 6 groups: control, methotrexate, casticin, myricetin, casticin+methotrexate, and myricetin+methotrexate. It was performed by methotrexate (20 mg/kg single dose, IP) in met...
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A literature review was performed to look at the interactions between alcohol and methotrexate in non-malignant disease. The evidence from research into psoriasis and inflammatory arthritis, and an overview of international and national guidelines, was amalgamated into some consensus recommendations.
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While most of the investigations into the causative events in the development of alcoholic liver disease (ALD) have been focused on multiple factors, increasing interest has centered around the possible role of immune mechanisms in the pathogenesis and perpetuation of ALD. This is because many of the clinical features of ALD suggest that immune effector mechanisms may be contributing to liver t...
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ژورنال
عنوان ژورنال: BMJ
سال: 1971
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5754.167-b